If the extracellular concentration of Na around a neuron gets reduced, the resting membrane potential becomes more negative (less positive).
Membrane potential is the electrical difference in electric potential between the interior (intracellular) and exterior (extracellular) in a biological cell. The resting membrane potential is determined by the uneven distribution of ions and the difference in permeability of the membrane to the various type of ions.
There are many types of ions found in neurons and their surrounding fluids, but the most abundant are:
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