Mutations in the protein retinoblastoma (rb) are often associated with cancer in the eye. The mutation might lead to cancer with a mutation that prevents Rb from becoming phosphorylated.
(myoo-TAY-shun) Any modification to a cell's DNA sequence. Mistakes in cell division can result in mutations, as can exposure to environmental DNA-damaging substances. Mutations may be negative, positive, or ineffective.
Base substitutions, deletions, and insertions are the three different forms of DNA mutations.
Depending on the situation or location, the impacts of mutation might be advantageous, detrimental, or neutral. The majority of non-neutral mutations are harmful. The effect of a mutation and its likelihood of being harmful increase generally with the number of base pairs that are affected by the mutation.
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