The soma becomes unable to respond to changes in the distal end of the axon this way axon affects the activity of a neuron.
Retrograde trophic assistance for growing neurons can interfere with their growth and frequently results in their death. Here, we describe the results of removing retrograde support from the isthmo-optic projection in chick embryos by preventing axoplasmic transport at the terminal sections of the axons, an action that is known to kill the isthmo-optic neurons in the long run. Neuron survival in the isthmo-optic nucleus was reduced even more swiftly. This unique effect persisted at 6 and 9 h after injection, but at longer survival durations, as was expected, the number of dead neurons rose significantly above control levels. According to our understanding of the temporary decrease in neuronal death, retrograde trophic signals contain both life- and death-promoting elements, with the former acting more quickly in this system.
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