Caspase-3 are the underlying biological processes used to activate caspases in both intrinsic and extrinsic pathways of apoptosis
Apoptosis is mediated by proteolytic enzymes called caspases. Caspases cause cell death by cleaving specific proteins in the cytoplasm and nucleus. Caspases are present in all cells as inactive precursors or procaspases and are normally activated by cleavage by other caspases to create the proteolytic caspase cascade. Apoptosis is a form of the programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cellular changes and death. These changes include blisters, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA degradation. Apoptosis is the process of the programmed of cell death. Used in the early stages of development to remove unwanted cells. For example, the one between the fingers of the developing hand. In adults, apoptosis is used to remove irreparably damaged cells from the body. Apoptosis also plays a role in cancer prevention.
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