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They are known as seven-transmembrane receptors because of the number of times (7 times) they travel through the cell membrane while interacting with G proteins.

Each GPCR is extremely specialized to a given signal, and humans alone have about 1,000 distinct GPCRs. GPCRs are made up of a single polypeptide that has been folded into a globular shape and encased in a cell's plasma membrane. The biggest family of receptors and membrane proteins in the human genome are G protein-coupled receptors (GPCRs), which have about 800 members, of which half are olfactory. Numerous endogenous signaling molecules can activate GPCRs, which are involved in various physiological processes.

As a result, we can state that the seven-transmembrane receptors are so named because they couple with G proteins and pass through the cell membrane seven times.

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