The primary mechanism by which addictive drugs can elicit increased dopaminergic transmission in the nucleus accumbens is by causing a pleasurable surge for the drug.
All addictive drugs, including alcohol, opioids, and cocaine, cause a pleasurable surge of the neurotransmitter dopamine in a part of the brain called the basal ganglia; neurotransmitters are chemicals that send messages between nerve cells. Every substance has generally different effects on the brain.
For a long time, it was thought that the euphoria we feel right after using narcotics was caused by the release of dopamine. Dopamine is likely a reinforcing agent for taking more of the drug, according to more recent studies. It increases a drug addict's desire for the substance.
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