Nicotinic receptors are found on the cell bodies of all postganglionic neurons.
The central and peripheral neurological systems use nicotinic acetylcholine receptors (nAChRs), prototypical cation-selective, ligand-gated ion channels, to transmit information quickly. Since nAChRs play a variety of physiological and pathological roles, they are crucial therapeutic targets.
On the postganglionic neurons of the sympathetic and parasympathetic cell bodies are nicotinic receptors. Acetylcholine (ACH) binding to nicotinic receptors results in an excitatory response.
Nicotinic receptors play a crucial role in accelerating neuronal and neuromuscular transmission. The somatic nervous system has nicotinic receptors (neuromuscular junctions in skeletal muscles). the nervous system's sympathetic and parasympathetic limbs (autonomic ganglia).
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