what is the major difference in how a potassium channel and the nuclear pore operate as a diffusion barrier?

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The major difference between potassium channel and the nuclear pore complex is that potassium channel is a single protein but nuclear pore complex is made of large number of different proteins.

A nuclear pore is a component of the vast protein complex known as a nuclear pore complex, which spans the nuclear envelope, the double membrane that encloses the nucleus of eukaryotic cells.

A vertebrate cell's nuclear envelope contains roughly 1,000 nuclear pore complexes (NPCs), while the exact amount varies depending on the cell type and stage of the life cycle. The 110 megadalton (MDa) human nuclear pore complex (hNPC) is a structure. Nucleoporins are the proteins that make up the nuclear pore complex (NPC), which is made up of 34 different nucleoporin proteins and at least 456 different protein components.

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