By maintaining a low concentration of oxaloacetate, a living cell overcome this unfavorable standard free-energy change during gluconeogenesis.
What is gluconeogenesis?
- A metabolic process known as gluconeogenesis (GNG) produces glucose from specific carbon sources that are not carbohydrates.
- It is a universal process that occurs in all living things, including fungi, bacteria, and other microbes.
- In vertebrates, the liver and, to a lesser extent, the kidney cortex is where gluconeogenesis primarily takes place.
- It is one of the two main methods that humans and many other animals utilize to maintain blood sugar levels and prevent low levels, the other being the destruction of glycogen (glycogenolysis) (hypoglycemia).
- Due to the tendency of rumen organisms to digest dietary carbohydrates, gluconeogenesis happens in ruminants independent of fasting, low-carbohydrate diets, exercise, etc.
- Many other animals go through the same process when they fast, starve, eat low carbohydrate foods, or exercise a lot.
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