The role of DNA ligase in the elongation of the lagging strand during DNA replication is to join Okazaki fragments together.
As the helix unwinds, DNA synthesis frequently resumes on the trailing strand, resulting in a large number of brief fragments known as "Okazaki fragments." The Okazaki fragments are united into one DNA molecule by DNA ligase.
By repairing breaks in the DNA's phosphodiester backbone that happen during replication, recombination, and as a result of DNA damage and repair, DNA ligases help to maintain the integrity of the genome.
Any breaks in the strand's sugar-phosphate backbone must be patched up by the DNA ligase. The DNA helicase unravels the strand. When replicating, binding proteins aid in maintaining the unwinding strand's open state. The tiny segments of duplicated DNA that originate from the lagging strand are known as Okazaki fragments.
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