When utilised as a treatment for HGPS, FTI's greatly increase cell migration and lower the number of aberrant nuclei present.
The lamin A (LMNA) gene mutation that leads to progeria. This gene produces a protein that keeps a cell's nucleus together. The protein develops a deficiency due to the gene alteration. Because of this, the nucleus becomes unstable, which is thought to be the root of premature ageing. In vitro, FTIs can specifically prevent Ras-dependent cell transformation, and in vivo, they can slow the growth of tumours.
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