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The frequency of triplet-repeat expansion would rise in the presence of a defective DNA polymerase that boosts strand slippage.
What is DNA polymerase?
A DNA polymerase belongs to a group of enzymes that catalyzing the synthesis of Dna strands using nucleoside triphosphates, which are the basic building blocks of DNA. These enzymes, which are necessary for DNA replication, typically function in groups to split one single original DNA duplex into two identical DNA duplexes. One nucleotide at the a time, DNA polymerase inserts nucleotides to a DNA strand's three primary (3')-end. DNA polymerases are needed to duplicate a cell's DNA each time it divides in order to send a replica of the original DNA molecule to each daughter cell. This is how genetic information is transmitted down through the generations.
These enzymes help the chemical process to happen.
Deoxynucleoside Triphosphate + DNAn ⇌ Pyrophosphate + DNAn+1.
What does a DNA polymerase do?
A dual DNA molecule is duplicated to two identical DNA molecules during the dna replication Process, which is carried out by DNA polymerase. With the help of the polymerase chain reaction, generally known as PCR, scientists have been able to duplicate DNA molecules inside test tubes. DNA polymerase alpha (Pol ), DNA polymerase delta (Pol ), & DNA polymerase epsilon (Pol ) are at least 3 DNA polymerases needed in eukaryotic genome replication (1). By creating an RNA/DNA hybrid primer, Pol starts the synthesis of both the leading & lagging strands of DNA.
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