Question

after nervous stimulation stops, what prevents ach in the synaptic cleft from continuing to stimulate contraction in the muscle fiber?

Answer 1

The prevents ACh in the synaptic cleft from continuing to stimulate contraction in the muscle fiber is acetylcholinesterase destroying the ACh.

ACh is broken down into acetate and choline by the enzyme acetylcholinesterase. ACh diffuses through the synaptic cleft. Action potential propagation in skeletal muscle fibers ceases when acetylcholine is removed from the synaptic cleft. In the somatic nervous system, acetylcholine is used at the neuromuscular junction to trigger the firing of motor neurons affecting voluntary movement.

There are two principles that govern the relationship between motor neuron activity and muscle strength. Pricing model and size principle. The neurotoxin NVP blocks ACh synthesis and vesamicol. Black widow spider venom promotes the release of ACh, whereas botulinum toxin and other substances inhibit its release.

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