The immune system's complement proteins circulate in the blood, coat microbe surfaces to make it easier for other components to get rid of them, and can even pierce microbial membranes to kill the bacteria.
Complement is a system of plasma proteins that can be activated by pathogens directly or indirectly through an antibody that is bound to the pathogen. C1, C2, and C4 are a few examples of complement proteins. The liver, in particular via hepatocytes, produces and secretes the majority of the complement proteins that are found in serum. However, not all of the body's locations that require complement activation are reached by serum. Their numbers range from C1 to C9. You can measure complement proteins separately or collectively. The two complement proteins that are most frequently examined are C3 and C4.
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