Since the nonpolar middles are hydrophobic, they are drawn together. Only organelles and proteins can pass through the thick wall created as a result.
Both the exterior and inner surfaces of biological membranes are hydrophobic. Nonpolar molecules can flow through the membrane as long as they are not too large since they do not interact with the polar hydrophobic/hydrophilic membrane. The cell membrane's inside is hydrophobic, meaning that water won't be attracted to it. In order to effectively separate fluid inside the cell from fluid outside the cell, phospholipids form a two-layer cell membrane.
As a result, the nonpolar middles are hydrophobic and are pulled toward one another. As a result, a thick barrier is formed so that only organelles and proteins can cross.
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