To administer the famotidine 20 mg by intermittent iv bolus every 12 hr, the nurse should set the iv pump to deliver 100 mg/hr. The nurse can do this by setting the rate on the infusion pump to 10 ml/hr.
The reason that 100 mg/hr is needed is because famotidine is a proton pump inhibitor (PPI), which means it works by decreasing gastric acid secretion. This drug has an onset of action of 30 minutes and can last up to 24 hours, so it should be administered every 12 hours. The dose is 20 mg, so 10 ml/hr is appropriate because each ml contains 2 mg of famotidine.
To calculate how much fluid is needed per hour, we first need to know how much fluid will be infused over 30 minutes (60 minutes divided by 30 minutes = 1/3).
Then we divide that number by how many milligrams of famotidine are in each milliliter of solution (2 mg / 10 ml = 0.2 mg/ml). Finally, multiply this number by how many milliliters are infused per hour (10 ml / 60 min = 0.17 ml/min). Our final answer is 0.05.
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