The coloumb force of attraction between the charges is negative.
[tex]F=\frac{q_1q_2}{4\pi\epsilon_or^2}[/tex]If the two charges are of opposite sign.
Then,
[tex]F=-\frac{q_1q_2}{4\pi\epsilon_or^2}[/tex]Here negative sign is indicating the attraction between the charges.
If both the charges are of same sign,
Then,
[tex]F=+\frac{q_1q_2}{4\pi\epsilon_or^2}[/tex]Positive sign representing the repulsion between the charges.