To find the equation of the parabola knowing the vertex (4,-5) and a point (-6,45) you have to use the vertex form:
[tex]y=a(x-h)^2+k[/tex]Replace the formula with:
Vertex:
h=4
k=-5
Point
x=-6
y=45
To calculate a
[tex]\begin{gathered} 45=a(-6-4)^2-5 \\ 45=a(-10)^2-5 \\ 45=a(100)-5 \\ 45=100a-5 \\ 45+5=100a \\ 50=100a \\ \frac{50}{100}=\frac{100a}{100} \\ a=\frac{1}{2} \end{gathered}[/tex]Now that we know the value of a we can write the equation of the parabola as:
[tex]y=\frac{1}{2}(x-4)^2-5[/tex]