Question

Histamine binds to the h1 g-protein-linked receptor to initiate the itchiness and airway constriction associated with an allergic response. If a mutation in the associated g-protein’s alpha subunit prevented the hydrolysis of gtp how would the allergic response change?.

Answer 1

Additionally, G protein mutations can result in either a loss or gain of function by inhibiting or stimulating signal transduction, which, in turn, results in the clinical phenotypes of an excess or a deficiency of hormones.

What renders the G protein's alpha subunit inactive?

The alpha subunit switches its GDP for a GTP when the neurotransmitter dopamine activates the receptor. The G protein subsequently breaks down. The beta and gamma subunits are left behind when the alpha subunit, which is carrying GTP, moves away.

The state of the receptor is altered when a ligand known as an agonist stimulates it. In order to activate G alpha, GTP must be exchanged for the bound GDP after G alpha separates from the receptor and G beta-gamma. The next step for G alpha is to activate more cell molecules.

GPCR mutations can result in hereditary and acquired conditions such retinitis pigmentosa (RP), hypo- and hyperthyroidism.

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