It results in these species being unculturable because their growth may depend on factors provided by other organisms in their natural environment.
Growth factors are specialized nutrients that certain species need but others do not. They may be byproducts of the metabolism of other organisms and are thus not available in a lab setting.
And while some media may include poisons due to the media itself or the water used to create it, it is still feasible to modify recipes to suit picky microorganisms.
Although bacteria as a whole have a remarkably varied range of metabolic processes, many species are highly specialized to lessen competition in their native habitats.
Because their growth may be dependent on essential growth elements supplied by other creatures in their natural habitat, it renders these species uncultivable.
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