Additionally from Africa came the Sickle-cell allele, which most likely developed when a mutation in a normal hemoglobin allele took place. The sickle-cell allele most likely developed close to Kinshasa (in Congo).
Since the mutation was first discovered there, heterozygous persons who had it had a higher probability of surviving. These people lived, reproduced more successfully, and via migration disseminated the mutation both inside and outside of that specific community.
An genetic condition where the red blood cells do not persist as long as normal red blood cells, have an irregular crescent form, and obstruct tiny blood arteries.
It turns out that because the mutation gives some resistance to malaria in certain places, HbS carriers have been naturally chosen. When the malaria parasite infects them, their red blood cells, which include some aberrant hemoglobin, have a tendency to sickle.
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