Question

Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endoderm to express liver-specific genes during liver formation.

Answer 1

• The notochord is of mesodermal origin and axial in structure.
• While the role of the notochord in endodermal development is most clearly one of dorsoventral patterning.

• At first glance, the early notochord appears to be structurally homogeneous along the AP axis and there is currently no evidence to indicate that subdomains may exhibit different functions.

• The evidence that the notochord is an important source of patterning, signals is undeniable, although the nature of these signals is only beginning to be understood.
• notochord plays a role in the development of the pancreas.
• Removal of the notochord from chick embryos, at a stage, when the notochord is in contact with the endoderm.
• The development of another endodermally derived tissue, the hypochord, is also regulated by the notochord.

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