In the liver, bilirubin is conjugated to glucuronide.
A class of enzymes called uridine-diphosphoglucuronic glucuronosyltransferase converts bilirubin to glucuronic acid inside the hepatocyte (UDPGT).
One of the many important detoxification processes used by the human body is glucuronidation. There are several distinct UDPGT isoforms, but UDPGT1A1 is the one that is physiologically significant for bilirubin glucuronidation.
The bilirubin's propionic acid side chains are modified by the enzyme by adding two glucuronide moieties. Bilirubin diglucuronide is the most common compound created under typical circumstances.
However, the majority of bilirubin may be converted as bilirubin glucuronide if the conjugation machinery is overloaded under circumstances where there is an excessive amount of bilirubin production.
Hydrogen bonds must be broken in order for bilirubin to be converted to its water-soluble form, which is necessary for liver and kidney excretion.
To learn more about bilirubin refer to:
https://brainly.com/question/14734896
#SPJ4
