Respuesta :
A client asks the nurse to explain the meaning of a narrow therapeutic index of a medication. The information the nurse should use to answer the question is a small margin exists between safe and toxic plasma levels.
Drugs with a narrow therapeutic index have modest variations in dosage or blood concentration that have the potential to cause serious therapeutic failures, adverse drug responses that pose a serious risk of death, or chronic or significant disability or incapacity.
The minimal effective concentration and the minimum hazardous concentration of several medications in the blood are just marginally different from one another. Small dose or blood/serum concentration changes with these medications have the potential to have hazardous effects.
It is employed by doctors with the arbitrary but helpful assumption that plasma concentrations or drug doses associated with a desirable therapeutic response are near to those associated with adverse events.
To learn more about the narrow therapeutic index refer to:
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