Thiamine diphosphate (ThDP) coenzyme is found in pyruvate decarboxylase that aids in decarboxylation.
The synthesis of the Escherichia coli EcPDH E1 subunit was evaluated for carbonization reactions with aliphatic ketoacids. EcPDH E1 is a thiamine diphosphate (ThDP)-dependent pyruvate dehydrogenase which is a coenzyme.
EcPDH E1 has been characterized in the past with regard to its biological characteristics because of its role in metabolism, but it has never been used for synthetic purposes.
Aliphatic aldehydes' alternate, thermodynamically controlled self-reaction was demonstrated to be restricted to modest levels of conversion, which we contend is because of their high hydration constants.
Additionally, a loss of stereoselectivity in the thermodynamically regulated method was shown to occur, rendering it impractical for aliphatic substrates.
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