In 1949, researchers severed a cat's reticular formation from higher brain regions; the cat lapsed into a permanent coma.
The reticular formation is an intricate network of brainstem neurons and nuclei that acts as a significant relay and integration hub for a variety of crucial brain systems to coordinate important processes for survival.
The centre of the neural connections between the spinal cord and the encephalon is represented by the brainstem reticular formation (RF). It supports functions linked to mood as well as autonomic, motor, sensory, behavioural, and cognitive processes.
If the core nuclei of the reticular formation are damaged bilaterally, it will result in permanent coma. The RAS and cerebral cortex both contribute to the maintenance of consciousness. Coma is brought on by lesions that damage a sizable portion of the cortex, a minor portion of the midbrain, or both.
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