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Friedrich Wöhler was the first to synthesize an organic compound from an inorganic substance. In 1828, he synthesized urea by slowly evaporating a water solution of ammonium cyanate, which he had prepared by adding silver cyanate to ammonium chloride.

How is urea synthesized ?

  • As part of the urea cycle, urea is produced in the bodies of many organisms, either from the oxidation of amino acids or from ammonia.
  • In this cycle, L-ornithine, citrulline, L-argininosuccinate, and L-arginine serve as intermediates while ammonia and L-amino aspartate's groups are transformed to urea.
  • N-acetylglutamate controls the liver's ability to produce urea. The kidneys then transport and eliminate urea as part of urine once it has been dissolved into the blood (in the reference range of 2.5 to 6.7 mmol/L).
  • Additionally, some urea is released in perspiration along with salt chloride and water.
  • Water molecules slowly displace the amine groups in water, resulting in the formation of ammonia, ammonium ions, and bicarbonate ions.
  • Because of this, stale, old pee smells more strongly than brand-new urine.

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