Ionotropic receptors are associated with ligand-activated ion channels, whereas metabotropic receptors are associated with signal proteins and g proteins.
Ionotropic and metabotropic receptors are two types of receptors that function in membrane transport and signal transduction.
Ionotropic receptors bind to ionic ligands such as K+, Na+, Cl–, and Ca2+.
Metabotropic receptors bind with non-ionic ligands such as chemical receptors or G protein-coupled receptors.
Metabotropic receptors act either directly or indirectly as signal transduction enzymes, or are linked to enzymes that have an extracellular domain recognizing a drug and an intracellular domain that catalyzes a biochemical response.
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