Which description of an enzyme substrate covalent intermediate is most likely correct?

The covalent intermediate will occur through the nucleophilic substitution by the side chain carboxyl of Asp14 at the electrophilic phosphorus atom in the substrate, displacing a leaving group.

Nucleophilic substitution reaction is a class of organic reactions where one nucleophile replaces another where reactive element replaces a less reactive element from its salt solution. The group which takes electron pair and displaced from the carbon is known as “leaving group” and the molecule on which substitution takes place known as “substrate”. The leaving group leaves as a neutral molecule or anion.

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Question :- Based on the information in the passage, which description of an enzyme-substrate covalent intermediate is most likely correct?

The substrate is covalently attached to:

A. Asp14 through the phosphorus atom of the phosphate group.

B. Asp14 through the oxygen atom of the phosphate group.

C. Asp16 through the phosphorus atom of the phosphate group.

D. Asp16 through the oxygen atom of the phosphate group.

Passage: Glycerol 3-phosphate phosphatases (G3PPs) are enzymes that catalyze the hydrolysis of the phosphoester bond in glycerol 3‑phosphate. The active site of G3PP contains Asp14 and Asp16, which act as a nucleophile and general acid, respectively, during catalysis.

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