The hormone which adjusts the rate of spermatogenesis by negative feedback onto the anterior pituitary is Inhibin.
- A negative feedback loop involving the hormones that control the male reproductive system helps to maintain adequate amounts of testosterone and sperm.
- The anterior pituitary gland's gonadotropic cells produce and secrete FSH, which promotes spermatogenesis.
- Inhibin While the location of production in the adult testis is still debatable, it is solely produced by the testis, primarily by the Sertoli cells in the prepubertal testis.
- By using a negative feedback mechanism, inhibin B regulates FSH secretion.
- Rising testosterone levels cause the anterior pituitary and hypothalamus to release inhibin which stops releasing GnRH, FSH, and LH, creating a negative feedback mechanism in males.
- When the sperm count is high, the Sertoli cells create the hormone inhibin, which is released into the circulation.
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