Question

Which of these amino acids are converted to succinyl coa? 1. isoleucine 2. valine 3. methionine 4. arginine 5. threonine a. 2, 3, and 4 b. 1, 3, and 5 c. 2 and 4 d. 2, 4, and 5 e. 1 and 5

Answer 1

Isoleucine ,methionine and  valine are converted to succinyl coA.

Isoleucine and valine can be converted to succinyl-CoA after converting first to propionyl-CoA. Since conversion of propionyl-CoA to succinyl-CoA requires vitamin B12, catabolism of these amino acids also requires the same vitamin.

Valine oxidation produces propionyl-coA, which is converted into methyl malonyl and succinyl-coA. Succinyl CoA can be formed from methyl malonyl CoA through the utilization of deoxyadenosyl-B12 (deoxy adenosyl cobalamin) by the enzyme methyl malonyl-CoA mutase.

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