The thyroid gland secretes a hormone that increases the body's metabolic rate, breathing rate, and heart rate.
The thyroid gland makes two hormones that it secretes into the bloodstream. One is called thyroxine ,this hormone contains four atoms of iodine and is often called T4. The other is called triiodothyronine, which contains three atoms of iodine and is often called T3. Activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5′-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis.
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