Respuesta :
The charge of the ions that pass through the synaptic channels in the nervous system determines the sign of the synaptic connections, or whether they are excitatory or inhibitory.
In general, excitatory channels are those that conduct positive ions, whereas inhibitory channels are those that conduct negative ions.
The precise balance between excitatory and inhibitory synaptic connections determines how brain networks behave. It is unknown, nevertheless, whether the presence or absence of synaptic connections between neurons within a network affects its ability to create and remain stable.
The behavioural output can be reversed by altering the sign of a synaptic connection inside a brain circuit. During the Caenorhabditis elegans escape reaction, the inhibitory tyramine-gated chloride channel, LGC-55, causes head relaxation and prevents forward movement.
An inhibitory LGC-55 anion channel's ion selectivity was changed to an excitatory LGC-55 cation channel. In the native brain circuit, the designed cation channel is correctly trafficked and causes behavioural reactions that are the opposite of those brought on by the activation of the LGC-55 anion channel.
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