True, The adaptive immune response requires exposure to specific epitopes for activation.
The adaptive immune system, also known as the acquired immune system, is a subsystem of the immune system made up of specialized, systemic cells and processes that either kill or prevent infections from multiplying. One of the two main immunity systems seen in vertebrates is the acquired immune system. White blood cells called lymphocytes carry out adaptive immune responses. There are two types of such reactions: antibody responses and cell-mediated immune responses, which are carried out by different types of lymphocytes known as B cells and T cells, respectively.
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