Frameshift mutation refers to the addition (insertion) or removal (deletion) of one or more coding sequence letters (nucleic acids).
The insertion or deletion of nucleotide bases in amounts that are not multiples of three is referred to as a frameshift mutation in a gene. This is significant because a cell reads the genetic code for proteins in groups of three nucleotides. These so-called "triplet codons" each stand for one of the 20 different amino acids that go into making a protein.
The entire gene sequence after the mutation will be misread if a mutation alters this regular reading frame. This may lead to the incorrect amino acids being added to the protein or the development of a codon that prevents the protein from getting longer.
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