Respuesta :
When B cell receptors are brought close enough together to cause B cells to be activated, the BRCs are said to be Crosslinked.
What are B cell receptors?
- The B cell receptor (BCR) is a transmembrane protein on the surface of a B cell.
- A B cell receptor is composed of a membrane-bound immunoglobulin molecule and a signal transduction moiety. The former forms a type 1 transmembrane receptor protein, and is typically located on the outer surface of these lymphocyte cells.
- Through biochemical signalling and by physically acquiring antigens from the immune synapses, the BCR controls the activation of the B cell.
- B cells are able to gather and grab antigens by engaging biochemical modules for receptor clustering, cell spreading, generation of pulling forces, and receptor transport, which eventually culminates in endocytosis and antigen presentation.
- B cells' mechanical activity adheres to a pattern of negative and positive feedbacks that regulate the quantity of removed antigen by manipulating the dynamic of BCR–antigen bonds directly.
- Particularly, grouping and spreading increase the relation of antigen with BCR, thereby proving sensitivity and amplification.
- On the other hand, pulling forces delinks the antigen from the BCR, thus testing the quality of antigen binding.
To learn more about B cell receptor: https://brainly.com/question/15076966
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