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A cluster of differentiation molecule is a glycoprotein used to identify and distinguish white blood cells.

The cluster of differentiation (CD) classification refers to proteins found on the surface of cells. Each unique surface molecule is assigned a different number, which allows cell phenotypes to be identified. These cell surface molecules of leukocytes are routinely detected with anti-leukocyte monoclonal antibodies. Clusters of antigens on the surface of leukocytes can be designated by their reactions with monoclonal antibodies.CD molecules are surface molecules expressed on cells of the immune system that play key roles in immune cell-cell communication and sensing the microenvironment.

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