Respuesta :
An increase in GDP binding to the Gα subunit of the G protein is NOT a likely outcome of glucagon binding to its receptor. the correct answer is option(a).
Glucagon causes conformational changes in its receptor, which is mostly found in the liver and kidney when it attaches to it. This results in the activation of heterotrimeric G proteins, particularly the Gs alpha subunit, which then begins signaling the activation of adenylyl cyclase enzymes.
Adenylate cyclase is activated by the Gs protein, which then catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), thereby raising intracellular cAMP levels. The glucagon signaling pathway is started by binding to specific receptors on the target cell membrane.
In addition to controlling the metabolism of carbohydrates, insulin and glucagon also have a number of physiologic functions. The binding of each hormone to receptors on the target cells starts the physiological effects of insulin and glucagon on the cell.
Therefore, the correct answer is option(a) because adenylate cyclase and protein kinase A activities as well as the level of cAMP are all enhanced once glucagon binds to its receptor and activates its associated G protein. In contrast, G protein activation encourages bound GDP dissociation and its exchange for GTP on the subunit.
The complete question is:
Which event is NOT a likely outcome of glucagon binding to its receptor? Increase in:
GDP binding to Gα subunit of the G protein
adenylate cyclase activity
protein kinase A activity
cAMP generation
To know more about glucagon refer to: https://brainly.com/question/15100163
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