Gap junctions for direct contact is used to cancer cells have inactive receptors on their plasma membrane so you need an alternate method of getting the signals into the cells.
What about cancer cell?
- The MAP kinase route, which controls cell proliferation, and the phosphoinositide 3-kinase (PI3K) pathway
- It controls cell metabolism and survival, are the two RAS signaling pathways that are most frequently linked to cancer.
- Signaling pathways are affected by cancer-causing mutations.
- The genomic changes in cancer cells can be linked to signaling pathways that regulate tumor-related functions and put in the perspective of distorted larger signaling networks that promote cancer progression.
- To transmit signals from the extracellular environment to the cell nucleus, where they activate particular genes necessary for cell division, growth, and differentiation.
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