Some combinations of recessive alleles cause problems so severe that a fetus may cease to develop. Such lethal allele combinations appear to alter Mendelian ratios because

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Such lethal allele combinations appear to alter Mendelian ratios because homozygotes for the lethal allele do not appear as a progeny class.

What are Mendel’s laws of inheritance?

  • Mendel proposed the law of inheritance of traits from the first generation to the next generation.
  • Law of inheritance is made up of three laws: Law of segregation, law of independent assortment and law of dominance.
  • The law of dominance states that recessive traits are always dominated or masked by dominant trait.
  • Lethal alleles are alleles that cause an organism to die only when present in a homozygous condition.
  • In case of lethal genes, only the heterozygous is able to survive in the progeny but they cause death if an organism carries two copies of the lethal allele. As a result homozygotes for the lethal allele do not appear as a progeny class.
  • Lethal alleles can cause death of an organism prenatally or any time after birth, though they commonly manifest early in development.

Learn more about Mendel's laws of inheritance here:

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