Such lethal allele combinations appear to alter Mendelian ratios because homozygotes for the lethal allele do not appear as a progeny class.
What are Mendel’s laws of inheritance?
- Mendel proposed the law of inheritance of traits from the first generation to the next generation.
- Law of inheritance is made up of three laws: Law of segregation, law of independent assortment and law of dominance.
- The law of dominance states that recessive traits are always dominated or masked by dominant trait.
- Lethal alleles are alleles that cause an organism to die only when present in a homozygous condition.
- In case of lethal genes, only the heterozygous is able to survive in the progeny but they cause death if an organism carries two copies of the lethal allele. As a result homozygotes for the lethal allele do not appear as a progeny class.
- Lethal alleles can cause death of an organism prenatally or any time after birth, though they commonly manifest early in development.
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