Question

Two factors affect the ability of drugs to destroy organisms in a ____________ community; the drug must be able to penetrate the thick sticky ____________ material surrounding the organisms, and the altered ____________ in biofilm organisms compared to their free-living counterparts must be addressed.

Answer 1

Two factors affect the ability of drugs to destroy organisms in a biofilm community; the drug must be able to penetrate the thick sticky extracellular material surrounding the organisms, and the altered phenotypes in biofilm organisms compared to their free-living counterparts must be addressed.

What are the factors affecting drug action?

Factors affecting drug action includes:

• Drug dosage: effect of drug increases with increased amount of drug up to the POINT OF RECEPTOR SATURATION
• Number of Receptors: receptors may be differentially expressed in one tissue to the next and, therefore, mediate different levels of biological responses.
• Disease states: disease states can effect drug pharmacology
• Drug Efficacy/Intrinsic activity: ability to activate or block a receptor: maximum effect a drug can produce regardless of the dose
• Drug Potency/Affinity: rate of drug-receptor binding and drug-receptor release: amount of drug needed to produce a particular effect: drug affinity for receptor.
• Genetic factors
• Route of administration: The drug injected by IV fluid is more effective.
• Rate and degree of absorption: The drug which is more absorbed is more effective.
• Effect of other drugs
• Tolerance

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