As the DNA is unwound to allow replication, torsion builds up which would prevent further movement of the replication fork. What general class of enzyme allows DNA to assume a more relaxed state

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18-07-2022
Biology

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As the DNA is unwound to allow replication, torsion builds up which would prevent further movement of the replication fork. What general class of enzyme allows DNA to assume a more relaxed state

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sonalimehtavaidikedu sonalimehtavaidikedu · Answer 1 · 2022-07-25T11:50:33+02:00

Topoisomerase enzyme allows DNA to assume a more relaxed state.

DNA topoisomerases (or topoisomerases) are enzymes that catalyze changes in the topological state of DNA, interconverting relaxed and supercoiled forms, linked (catenated) and unlinked species, and knotted and unknotted DNA. This enzyme prevents the DNA double helix in front of the replication fork from winding up too tightly as the DNA unwinds

DNA topoisomerases unravel the twists in DNA that occur as a result of DNA transcription and replication. DNA topoisomerases I and II present in cells cleaves the DNA backbone on one or two strands, and it releases the torsional stress and then displacement of the broken DNA backbone.

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