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Subcutaneous nodules and Pericarditis  are considered major criteria used in the diagnosis of acute rheumatic fever.

Rheumatic fever is an untreated throat streptococcal infection-related consequence that causes inflammation of the joints, heart, skin, and neurological system. While rheumatic fever can occur at any age, it tends to affect children and teenagers between the ages of 5 and 15.

Depending on which body organs become damaged, rheumatic fever symptoms might vary substantially. Rheumatic fever symptoms include joint discomfort, fever, and swelling. Heart inflammation (carditis)-related chest discomfort or palpitations as well as tiny nodules under the skin.

Some children with heart inflammation do not even exhibit any symptoms, and the inflammation is only identified until there is cardiac damage years later. Other children experience chest pain brought on by heart sac inflammation ( pericarditis). Children may experience both chest pain and a high fever.

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