Histamine inhibits the chemotaxis which is the movement of cells along the gradient.
Histamine:
It is a neurotransmitter that is released by the mast cells in response to an allergen that causes an allergic reaction. It is responsible for redness of the inflamed area, heating, movement of leukocytes, and defense proteins to the site of injury. Histamine is responsible for vasodilation and increased permeability. The immune cells move to the site of injury and cause the flow of blood to the injured site. It plays an important role in allergic and hypersensitivity reactions. Histamine is also responsible for gastric secretion, smooth muscle contraction, and itching.
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