Question

Dopamine hydrochloride injection is available in 5-ml ampuls containing 40 mg of dopamine hydrochloride per milliliter. the injection must be diluted before administration. if a physician wishes to use sodium chloride injection as the diluent and wants a dilution containing 0.04% w/v of dopamine hydrochloride, how many mililiters of sodium chloride iniection should be added to 5 ml of the injection?

Answer 1

495 milliliters of sodium chloride injection should be added to 5 ml of the injection

Given :

Weight of Dopamine Hydrochloride 5 ml = 40 mg

                  W/V % = 0.04 %

Volume of Dopamine Hydrochloride = 5ml

1 ml contain = 40 mg

5 ml   =  5  * 40 mg

          = 200 mg

         = 0.2 g        ( 1g = 1000mg)

(W/V) %   = { weight of solute (g) / volume of solution (ml)  } * 100

0.04%    = { 0.2 / volume of solution (ml)} * 100

0.04       =  0.2 / volume of solution (ml)  * 100

Vol of solution (ml) = 0.2 * 100 / 0.04 = 500 ml

Vol of solution = Vol . of solute + Vol. of solvent

Volume of solvent ( sodium chloride injection)

                     =  (Vol of solution) - ( Vol . of solute)

                     =  500 ml - 5 ml

                     = 495 ml  

Thus , answer is 495 mL .

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