Question

In an experiment on an animal model in which the synapsin gene is knocked out, you measure the density of synaptic vesicles in the presynaptic terminal within the active zone and outside the active zone in both knockout and control animals. Given what you know about the function of synapsin, what would you expect to find

Answer 1

When the synapsin gene is knocked out there will be fewer vesicles in the reserve pool in knockout animals than in controls.

Synapsin

Synapsins are a family of evolutionarily conserved phosphoproteins seen in all synapses. They are reversibly associated with synaptic vesicles. They are responsible for holding the vesicles in place.

There are different isoforms of synapsins. Both synapsin I and synapsin II are the major isoforms of synapsin and are related to the elongation of axons and the synaptic vesicle fusion kinetics regulation. Synapsin III is involved in neurogenesis and synaptogenesis regulation.

Functions of Synapsin

• Presynaptic terminal formation
• Regulating the vesicle reserve pool
• Axon elongation
• Docking of synaptic vesicles
• Synaptogenesis

Note: - The question seems to be missing the options which possibly could be,

1. "There will be fewer vesicles in the reserve pool in knockout animals than in controls
2. There will be more vesicles in the reserve pool in knockout animals than in controls
3. There will be no vesicles in the reserve pool in knockout animals than in controls
4. There will be no vesicles docked in the active zone in knockout animals
5. There will be no difference between knockout animals and controls"

Learn more about synapses here:

https://brainly.com/question/27381250

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