Strengthening some synapses and weakening others establishes neural circuits that contain memories; the low-frequency stimulation of synaptic inputs to a cell can decrease their strength in a phenomenon known as long-term depression.
The effect of long-term depression can arise from neural effect of synapses. The synaptic impulses start to decrease gradually when a person is suffering from long-term depression. This decreased neural synapses arise from long-term exposure to stress that is chronic. It can also stem from anxiety. The continuous exposure of the neurons to stress and anxiety can also lead to degeneration and depletion of the cells present in the nervous system. Also the cortisol levels rise during depression and it is regulated by the hippocampus. This leads to a delay or restriction in the developing neurons inside the brain. Long-term depression can lead to increased chances of getting addicted to alcohol or drugs.
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