Question

An Rh negative mother has just given birth to an Rh positive baby after 18 hours of strenuous labor. Her rosette test was positive. Upon performing the Kleihauer-Betke stain procedure, the percentage of fetal cells is found to be 1.9%. The mother's total blood volume is 5,000 mL. What dose of Rh Ig (RhoGam) should be administered to the mother

Answer 1

The mother should have 4 vials of Rh Ig administered.

How to calculate the value?

Rh immune globulin is used to help prevent an Rh-negative mother from becoming sensitized to the D antigen from an Rh-positive baby.

To calculate how many vials are needed, the following formula can be employed:

KB% x blood volume = volume of baby blood

In this case: 1.9% x 5,000mL = 95 mL baby blood in maternal circulation

95mL / 30 mL per Rh Ig vial = 3.17 vials

This equals 3 vials (after rounding), with the addition of 1 extra vial = the mother should have 4 vials of Rh Ig administered.

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