Peptic ulcer disease can be caused by the failure of tight junctions. Thus, the correct option is A.
Peptic ulcer disease may be defined as a circumstance in which bitter and painful sores or ulcers evolve in the lining of the stomach or the first part of the small intestine which is the duodenum.
A tight junction is responsible for lining the wall of the intestine or stomach. It helps in the prevention of the passage of digestive enzymes through the space between adjacent locations inside the stomach or small intestine.
If this junction breaches, it results in damage to the wall of the stomach by the acids that help digest food and causes the peptic ulcer disease which is infected by a bacterial organism known as Helicobacter pyroli.
Therefore, it is well described above.
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