Coagulase biochemical test requires rabbit plasma as a reagent and its results are determined by observation of thickening of the medium.
A coagulase test is a biochemical test that uses the ability to manufacture the coagulase enzyme to distinguish Staphylococcus aureus from other Staphylococci species such as S. epidermidis and S. saprophyticus.
Because it interacts with the fibrinogen present on the host's cell surface, the coagulase enzyme acts as a virulence factor in several organisms. Coagulase-producing organisms usually have a protective barrier around them, which increases their pathogenicity and immune system resistance.
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